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Publications

Here is the list of works published by the researchers of the Operative Unit since 2015.
Links to extended lists of publications for each researcher are available in the staff page.

2022

  • Catalano A, Iacopetta D, Ceramella J, Scumaci D, Giuzio F, Saturnino C, Aquaro S, Rosano C, Sinicropi MS. Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies. Molecules 2022, 27(3):616. doi: 10.3390/molecules27030616
  • Catalano, A.; Iacopetta, D.; Ceramella, J.; Mariconda, A.; Rosano, C.; Scumaci, D.; Saturnino, C.; Longo, P.; Sinicropi, M.S. New Achievements for the Treatment of Triple-Negative Breast Cancer. Appl. Sci. 22022, 12, 5554. doi: 10.3390/app12115554
  • Ceramella, J.; Mariconda, A.; Sirignano, M.; Iacopetta, D.; Rosano, C.; Catalano, A.; Saturnino, C.; Sinicropi, M.S.; Longo, P. Novel Au Carbene Complexes as Promising Multi-Target Agents in Breast Cancer Treatment. Pharmaceuticals 2022, 15, 507. doi: 10.3390/ph15050507
  • Ceramella, J.; Chimento, A.; Iacopetta, D.; De Luca, A.; Coronel Vargas, G.; Rosano, C.; Pezzi, V.; Saturnino, C.; Sinicropi, M.S. A Resveratrol Phenylacetamide Derivative Perturbs the Cytoskeleton Dynamics Interfering with the Migration Potential in Breast Cancer. Appl. Sci. 2022, 12, 6531. doi: 10.3390/app12136531
  • Cuadros Gamboa AL, Benfante R, Nizzardo M, Bachetti T, Pelucchi P, Melzi V, Arzilli C, Peruzzi M, Reinbold RA, Cardani S, Morrone A, Guerrini R, Zucchi I, Corti S, Ceccherini I, Piumelli R, Nassi N, Di Lascio S, Fornasari D. Generation of two hiPSC lines (UMILi027-A and UMILi028-A) from early and late-onset Congenital Central hypoventilation Syndrome (CCHS) patients carrying a polyalanine expansion mutation in the PHOX2B gene. Stem Cell Res. 2022, 61:102781. doi: 10.1016/j.scr.2022.102781
  • Escelsior A, Cogorno L, Sukkar SG, Amerio A, Donini LM, Bellomo M, Iervasi E, Amore M, Saverino D. Anti-hypothalamus autoantibodies in anorexia nervosa: a possible new mechanism in neuro-physiological derangement? Eat Weight Disord. 2022 Mar 16. doi: 10.1007/s40519-022-01388-5.
  • Izzotti A, Fracchia E, Rosano C, Comite A, Belgioia L, Sciacca S, Khalid Z, Congiu M, Colarossi C, Blanco G, Santoro A, Chiara M, Pulliero A. Efficacy of High-Ozonide Oil in Prevention of Cancer Relapses Mechanisms and Clinical Evidence. Cancers. 2022; 14(5):1174. doi: 10.3390/cancers14051174
  • Lusardi M, Rotolo C, Ponassi M, Iervasi E, Rosano C, Spallarossa A. One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives. ChemMedChem 2022, e202100670. doi: 10.1002/cmdc.202100670
  • Marchiano M, Iervasi E, Pesce G, Rumbullaku M, Foti C, Fumarulo R, Parodi A, Bagnasco M, Tampoia M, Saverino D. Increased concentration of soluble leukocyte-associated immunoglobulin-like receptor (LAIR) in sera from patients with blistering diseases: possible pathophysiological implications? Minerva Med 2022 Feb 14. doi: 10.23736/S0026-4806.22.07652-2
  • Marconi S, Croce M, Chiorino G, Rossi G, Guana F, Profumo A, Ostano P, Alama A, Longo L, De Luca G, Dono M, Dal Bello MG, Ponassi M, Rosano C, Romano P, Cavalieri Z, Grassi M, Tagliamento M, Zullo L, Venturi C, Dellepiane C, Mastracci L, Bennicelli E, Pronzato P, Genova C, Coco S. A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients. Cancers (Basel). 2022 Jul 14;14(14):3412. doi:10.3390/cancers14143412.
  • Ponzoni M, Bachetti T, Corrias MV, Brignole C, Pastorino F, Calarco E, Bensa V, Giusto E, Ceccherini I, Perri P. Recent advances in the developmental origin of neuroblastoma: an overview. J Exp Clin Cancer Res. 2022 Mar 11;41(1):92. doi: 10.1186/s13046-022-02281-w

2021

  • Bachetti T, Bagnasco S, Piumelli R, Palmieri A, Ceccherini I. A common 3’UTR variant of the PHOX2B gene is associated with infant life-threatening and sudden death events in the Italian population. Front Neurol 2021, 12:642735. doi: 10.3389/fneur.2021.642735
  • Bachetti T, Rosamilia F, Bartolucci M, Santamaria G, Mosconi M, Sartori S, De Filippo MR, Di Duca M, Obino V, Avanzini S, Mavilio D, Candiani S, Petretto A, Pini Prato A, Ceccherini I, Lantieri F. The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling. Int J Mol Sci 2021, 22(8):3831. doi: 10.3390/ijms22083831
  • Barbarossa A, Catalano A, Ceramella J, Carocci A, Iacopetta D, Rosano C, Franchini C, Sinicropi MS. Simple Thalidomide Analogs in Melanoma: Synthesis and Biological Activity. Applied Sciences 2021, 11(13):5823. DOI: 10.3390/app11135823
  • Bozzo M, Lacalli TC, Obino V, Caicci F, Marcenaro E, Bachetti T, Manni L, Pestarino M, Schubert M, Candiani S. Amphioxus neuroglia: Molecular characterization and evidence for early compartmentalization of the developing nerve cord. Glia 2021, 69(7):1654-1678. doi: 10.1002/glia.23982
  • Catalano A, Sinicropi MS, Iacopetta D, Ceramella J, Mariconda A, Rosano C, Scali E, Saturnino C, Longo P. A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents. Applied Sciences 2021, 11(13):6027. DOI: 10.3390/app11136027
  • Daga E, Budroni M, Multineddu C, Cosentino S, Deplano M, Romano P, Comunian R. The MicroBioDiverSar Project: Exploring the Microbial Biodiversity in Ex Situ Collections of Sardinia. Sustainability 2021, 13:(15),8494. doi: 10.3390/su13158494
  • Del Prete E, Facchiano A, Profumo A, Angelini C, Romano P. GeenaR: a web tool for reproducible MALDI-TOF analysis. Frontiers in Genetics. 29 March 2021. 12:635814. doi: 10.3389/fgene.2021.635814
  • Iacopetta D, Ceramella J, Rosano C, Mariconda A, Pellegrino M, Sirignano M, Saturnino C, Catalano A, Aquaro S, Longo P, Sinicropi MS. N-Heterocyclic Carbene-Gold(I) Complexes Targeting Actin Polymerization. Applied Sciences 2021, 11(12):5626. DOI: 10.3390/app11125626
  • Iervasi E, Saverino D. Covid-19: why did Italy decide to keep schools closed? Minerva Pediatr (Torino) 2021, 5897. DOI: 10.23736/S2724-5276.21.05897-3
  • Milanese M, Bonifacino T, Torazza C, Provenzano F, Kumar M, Ravera S, Zerbo AR, Frumento G, Balbi M, Nguyen TPN, Bertola N, Ferrando S, Viale M, Profumo A, Bonanno G. Blocking glutamate mGlu5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1G93A mouse model of amyotrophic lateral sclerosis. Br J Pharmacol 2021, 178(18):3747–3764. DOI: 10.1111/bph.15515
  • Pulliero A, Profumo A, Rosano C, Izzotti A, Saccà SC. Therapeutic Hydrogel Lenses and the Antibacterial and Antibiotic Drugs Release. Applied Sciences 2021, 11(4):1931. DOI: 10.3390/app11041931
  • Schijns V, Majhen D, van der Ley P, Thakur A, Summerfield A, Berisio R, Nativi C, Fernández-Tejada A, Alvarez-Dominguez C, Gizurarson S, Zamyatina A, Molinaro A, Rosano C, Jakopin Ž, Gursel I, McClean S. Rational Vaccine Design in Times of Emerging Diseases: The Critical Choices of Immunological Correlates of Protection, Vaccine Antigen and Immunomodulation. Pharmaceutics 2021, 13(4):501. DOI: 10.3390/pharmaceutics13040501
  • Spallarossa A, Lusardi M, Caneva C, Profumo A, Rosano C, Ponassi M. Bicyclic Basic Merbarone Analogues as Antiproliferative Agents. Molecules 2021, 26(3):557. DOI: 10.3390/molecules26030557
  • Zhou A, Rand CM, Hockney SM, Niewijk G, Reineke P, Speare V, Berry-Kravis EM, Zhou L, Jennings LJ, Yu M, Ceccherini I, Bachetti T, Pennock M, Yap KL, Weese-Mayer DE. Paired-like homeobox gene (PHOX2B) nonpolyalanine repeat expansion mutations (NPARMs): genotype-phenotype correlation in congenital central hypoventilation syndrome (CCHS). Genet Med 2021, May 6. doi: 10.1038/s41436-021-01178-x

2020

  • Bachetti T, Ceccherini I. Causative and common PHOX2B variants define a broad phenotypic spectrum. Clin Genet. 2020, 97(1):103-113. doi: 10.1111/cge.13633
  • Barboro P, Benelli R, Tosetti F, Costa D, Capaia M, Astigiano S, Venè R, Poggi A, Ferrari N. Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk. Carcinogenesis 2020, 41(9):1246-1252. doi: 10.1093/carcin/bgaa053
  • Beitia M, Romano P, Larrinaga G, Solano-Iturri JD, Salis A, Damonte G, Bruzzone M, Ceppi M, Profumo AThe Activation of Prothrombin Seems to Play an Earlier Role Than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation. Diagnostics 2020 Dec 11, 10(12), 1077. doi: 10.3390/diagnostics10121077
  • Ben Toumia I, Sobeh M, Ponassi M, Banelli B, Dameriha A, Wink M, Chekir Ghedira L, Rosano C. A Methanol Extract of Scabiosa atropurpurea Enhances Doxorubicin Cytotoxicity against Resistant Colorectal Cancer Cells In Vitro. Molecules 2020, 25(22):5265. DOI: 10.3390/molecules25225265
  • Benelli R, Costa D, Mastracci L, Grillo F, Olsen MJ, Barboro P, Poggi A, Ferrari N. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers (Basel) 2020, 12(4):971. doi: 10.3390/cancers12040971
  • Brullo C, Rapetti F, Alfei S, Maric I, Rizzelli F, Mapelli M, Rosano C, Viale M, Bruno O. Discovery of New Antiproliferative Imidazopyrazole Acylhydrazones Able To Interact with Microtubule Systems. ChemMedChem 2020, 15(11):961-969. DOI: 10.1002/cmdc.202000122
  • Candiani S, Carestiato S, Mack AF, Bani D, Bozzo M, Obino V, Ori M, Rosamilia F, De Sarlo M, Pestarino M, Ceccherini I, Bachetti T. Alexander Disease Modeling in Zebrafish: An In Vivo System Suitable to Perform Drug Screening. Genes (Basel) 2020, 11(12):149. doi: 10.3390/genes11121490
  • Cattrini C, Barboro P, Rubagotti A, Zinoli L, Zanardi E, Capaia M, Boccardo F. Integrative Analysis of Periostin in Primary and Advanced Prostate Cancer. Translational Oncology 2020, 13:7. doi: 10.1016/j.tranon.2020.100789
  • Cattrini C, Capaia M, Boccardo F, Barboro P. Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study. Cancer Treat Res Commun. 2020, 25:100221. doi: 10.1016/j.ctarc.2020.100221
  • Cattrini C, Soldato D, Rubagotti A, Zinoli L, Zanardi E, Barboro P, Messina C, Castro E, Olmos D, Boccardo F. Epidemiological Characteristics and Survival in Patients with De Novo Metastatic Prostate Cancer. Cancers (Basel) 2020, 12(10):2855. doi: 10.3390/cancers12102855
  • Cattrini C, Zanardi E, Rubagotti A, Zinoli L, Capaia M, Barboro P, Boccardo F. Real-world survival improvements in patients with newly diagnosed metastatic prostate cancer treated in the United States. Journal of Clinical Oncology 2020, 38(Suppl 6):48. doi: 10.1200/JCO.2020.38.6_suppl.48
  • Ceramella J, Mariconda A, Iacopetta D, Saturnino C, Barbarossa A, Caruso A, Rosano C, Sinicropi MS, Longo P. From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases. Bioorg Med Chem Lett. 2020 30(3):126905. doi: 10.1016/j.bmcl.2019.126905.
  • Ceramella J, Mariconda A, Rosano C, Iacopetta D, Caruso A, Longo P, Sinicropi MS, Saturnino C. α-ω Alkenyl-bis-S-Guanidine Thiourea Dihydrobromide Affects HeLa Cell Growth Hampering Tubulin Polymerization. ChemMedChem 2020, 15(23):2306-2316. DOI: 10.1002/cmdc.202000544
  • Di Cristo F, Calarco A, Digilio FA, Sinicropi MS, Rosano C, Galderisi U, Melone MAB, Saturnino C, Peluso G. The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity. Int J Mol Sci 2020, 21(19):7431. DOI: 10.3390/ijms21197431
  • Duval C, Profumo A, Aprile A, Salis A, Millo E, Damonte G, Gauer JS, Ariëns RAS, Rocco M. Fibrinogen αC-regions are not directly involved in fibrin polymerization as evidenced by a “Double-Detroit” recombinant fibrinogen mutant and knobs-mimic peptides. J Thromb Haemost 2020 Apr;18(4):802-814. doi: 10.1111/jth.14725
  • Giusti A, Camellino D, Saverino D, Iervasi E, Girasole G, Bianchi G, Papapoulos SE. Zoledronate decreases CTLA-4 in vivo and in vitro independently of its action on bone resorption. Bone 2020, 138:115512. DOI: 10.1016/j.bone.2020.115512
  • Iacopetta D, Catalano A, Ceramella J, Barbarossa A, Carocci A, Fazio A, La Torre C, Caruso A, Ponassi M, Rosano C, Franchini C, Sinicropi MS. Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorg Chem 2020, 105:104440. DOI: 10.1016/j.bioorg.2020.104440
  • Iacopetta D, Lappano R, Mariconda A, Ceramella J, Sinicropi MS, Saturnino C, Talia M, Cirillo F, Martinelli F, Puoci F, Rosano C, Longo P, Maggiolini M. Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells. Int J Mol Sci 2020, 21(20):7797. DOI: 10.3390/ijms21207797
  • Iacopetta D, Rosano C, Sirignano M, Mariconda A, Ceramella J, Ponassi M, Saturnino C, Sinicropi MS, Longo P. Is the Way to Fight Cancer Paved with Gold? Metal-Based Carbene Complexes with Multiple and Fascinating Biological Features. Pharmaceuticals (Basel) 2020, 13(5):91. DOI: 10.3390/ph13050091
  • Iervasi E, Auricchio R, Strangio A, Greco L, Saverino D. Serum IL-21 levels from celiac disease patients correlates with anti-tTG IgA autoantibodies and mucosal damage. Autoimmunity 2020 DOI: 10.1080/08916934.2020.1736047
  • Insolia V, Priori EC, Gasperini C, Coppa F, Cocchia M, Iervasi E, Ferrari B, Besio R, Maruelli S, Bernocchi G, Forlino A, Bottone MG. J Comp Neurol 2020, 528(1):61-80. DOI: 10.1002/cne.24735
  • Musi CA, Agrò G, Santarella F, Iervasi E, Borsello T. JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases. Cells 2020, 9(10):2190. DOI: 10.3390/cells9102190
  • Pulliero A, Profumo A, Izzotti A, Saccà SC. Release of Aloe vera Extracts from Therapeutic Lenses. Applied Sciences 2020, 10(24):9055. doi: 10.3390/app10249055
  • Schijns V, Fernández-Tejada A, Barjaktarović Ž, Bouzalas I, Brimnes J, Chernysh S, Gizurarson S, Gursel I, Jakopin Ž, Lawrenz M, Nativi C, Paul S, Pedersen GK, Rosano C, Ruiz-de-Angulo A, Slütter B, Thakur A, Christensen D, Lavelle EC. Modulation of immune responses using adjuvants to facilitate therapeutic vaccination. Immunol Rev 2020, 296(1):169-190. DOI: 10.1111/imr.12889
  • Visconti P, Parodi F, Parodi B, Casarino L, Romano P, Buccarelli M, Pallini R, D’Alessandris G, Montori A, Pilozzi E, Ricci-Vitiani L. STR profiling for the authentication of cancer stem-like cells.  International Journal of Cancer. 2020. doi: 10.1002/ijc.33370

2019

  • Cattrini C, Rubagotti A, Zinoli L, Cerbone L, Zanardi E, Capaia M, Barboro P, Boccardo F. Role of Circulating Tumor Cells (CTC), Androgen Receptor Full Length (AR-FL) and Androgen Receptor Splice Variant 7 (AR-V7) in a Prospective Cohort of Castration-Resistant Metastatic Prostate Cancer Patients. Cancers (Basel) 2019, 11(9):1365. doi: 10.3390/cancers11091365
  • De Vero L, Boniotti MB, Budroni M, Buzzini P, Cassanelli S, Comunian R, Gullo M, Logrieco AF, Mannazzu I, Musumeci R, Perugini I, Perrone G, Pulvirenti A, Romano P, Turchetti B, Varese GC. Preservation, Characterization and Exploitation of Microbial Biodiversity: The Perspective of the Italian Network of Culture Collections. Microorganisms. 2019 7(12) E685. doi: 10.3390/microorganisms7120685.
  • Iervasi E, Strangio A, Saverino D. Hypothalamic expression of PD-L1: does it mediate hypothalamitis? Cell Mol Immunol 2019, 16(6):625-626 DOI: 10.1038/s41423-019-0232-2
  • Pelicci S, Oneto M, Di Bona M, Cainero I, Barboro P, Diaspro A, Lanzano L. Chromatin Nanoscale Organization Investigated by FLIM-FRET and STED Superresolution Microscopy. Biophysical Journal 2019, 116:147a. doi: 10.1016/j.bpj.2018.11.965
  • Romano P, Céol A, Dräger A, Fiannaca A, Giugno R, La Rosa M, Milanesi L, Pfeffer U, Rizzo R, Shin SY, Xia J, Urso A. The 2017 Network Tools and Applications in Biology (NETTAB) workshop: aims, topics and outcomes. BMC Bioinformatics. 2019 20(Suppl 4):125. doi: 10.1186/s12859-019-2681-0.
  • Sacca SC, Pulliero A, Maestra S, Geretto M, Profumo A, Ilderbayev O, Rosano C, Izzotti A. Protection of trabecular meshwork cells by eyedrops containing high concentration of polyphenols. New Front Ophthalmol, 2019, 5:1-7 doi: 10.15761/NFO.1000228.
  • Viale M, Vecchio G, Maric I, Cilli M, Aprile A, Ponzoni M, Fontana V, Priori EC, Bertone V, Rocco M. Fibrin gels entrapment of a doxorubicin-containing targeted polycyclodextrin: Evaluation of in vivo antitumor activity in orthotopic models of human neuroblastoma. Toxicology and applied pharmacology 385, 114811 2019. doi: 10.1016/j.taap.2019.114811.
  • Viale M, Vecchio G, Monticone M, Bertone V, Giglio V, Maric I, Cilli M, Bocchini V, Profumo A, Ponzoni M, Emionite L, Rocco M. Fibrin Gels Entrapment of a Poly-Cyclodextrin Nanocarrier as a Doxorubicin Delivery System in an Orthotopic Model of Neuroblastoma: Evaluation of In Vitro Activity and In Vivo Toxicity. Pharmaceutical research 2019, 36 (8), 115 doi: 10.1007/s11095-019-2636-1.

2018

  • Alfei S, Catena S, Ponassi MRosano C, Zoppi V, Spallarossa A. Hydrophilic and amphiphilic water-soluble dendrimer prodrugs suitable for parenteral administration of a non-soluble non-nucleoside HIV-1 reverse transcriptase inhibitor thiocarbamate derivative. Eur J Pharm Sci 2018 Nov 1;124:153-164. doi: 10.1016/j.ejps.2018.08.036. Epub 2018 Aug 28.
  • Bianchi G, Ravera S, Traverso C, Amaro A, Piaggio F, Emionite L, Bachetti T, Pfeffer U, Raffaghello L. Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting ATP-synthase activity. Carcinogenesis. 2018, 39(9):1141-1150. doi: 10.1093/carcin/bgy076
  • Bonaccorsi P, Papalia T, Barattucci A, Salerno TMG, Rosano C, Castagnola P, Viale M, Monticone M, Campagna S, Puntoriero F. Localization-controlled two-color luminescence imaging via environmental modulation of energy transfer in a multichromophoric species. Dalton Trans 2018 Mar 26;47(13):4733-4738. doi: 10.1039/c7dt04850e.
  • Brookes E, Rocco M. Recent advances in the UltraScan SOlution MOdeler (US SOMO) hydrodynamic and small-angle scattering data analysis and simulation suite. Eur. Biophys. J. 2018, 47, 855–864. doi: 10.1007/s00249-018-1296-0
  • Capaia M, Granata I, Guarracino M, Petretto A, Inglese E, Cattrini C, Ferrari N, Boccardo F, Barboro P. A hnRNP K-AR Related Signature Reflects Progression toward Castration-Resistant Prostate Cancer. International Journal of Molecular Sciences 2018, 19:1920. doi: 10.3390/ijms19071920
  • Di Lascio S, Benfante R, Di Zanni E, Cardani S, Adamo A, Fornasari D, Ceccherini I, Bachetti T. Structural and functional differences in PHOX2B frameshift mutations underlie isolated or syndromic congenital central hypoventilation syndrome. Hum Mutat. 2018, 39(2):219-236. doi: 10.1002/humu.23365
  • Diaspro A, Cainero I, Lanzanò L, Bianchini P, Vicidomini G, Cella Zanacchi F, Pesce L, Pelicci S, Oneto M, Di Bona M, FarettaM, Barboro P, Le Gratiet A. A Liquid Tunable Microscope as a New Paradigm in Optical Microscopy to Paint 4D Chromatin Organisation in the Cell Nucleus. Biophysical Journal 2018, 114(3):347a. doi: 10.1016/j.bpj.2017.11.1937
  • Frosina G, Profumo A, Marubbi D, Marcello D, Ravetti JL, Daga A. ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration. Radiat Oncol 2018 Apr 23;13(1):76. doi: 10.1186/s13014-018-1020-3.
  • Frosina G, Ravetti JL, Corvò R, Fella M, Garrè ML, Levrero F, Marcello D, Marubbi D, Morana G, Mussap M, Neumaier CE, Profumo A, Raso A, Rosa F, Vagge S, Vecchio D, Verrico A, Zona G, Daga A. Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1]. Sci Rep 2018 Sep 21;8(1):14191. doi: 10.1038/s41598-018-32578-w.
  • Geretto M, Ponassi M, Casale M, Pulliero A, Cafeo G, Malagreca F, Profumo A, Balza E, Bersimbaev R, Kohnke FH, Rosano C, Izzotti A. A novel calix[4]pyrrole derivative as a potential anticancer agent that forms genotoxic adducts with DNA. Sci Rep 2018 Jul 23;8(1):11075. doi: 10.1038/s41598-018-29314-9.
  • Gioria S, Urbán P, Hajduch M, Barboro P, Cabaleiro N, La Spina R, Chassaigne H. Proteomics study of silver nanoparticles on Caco-2 cells. Toxicology in Vitro 2018, 50:347-372. doi: 10.1016/j.tiv.2018.03.015
  • Romano P, Beitia San Vicente M, Profumo A. A mass spectrometry based method and a software tool to assess degradation status of serum samples to be used in proteomics for biomarker discovery. J Proteomics 2018 Feb 20;173:99-106. doi: 10.1016/j.jprot.2017.12.004. Epub 2017 Dec 12.
  • Romano PProfumo A, Facchiano A. Pre-Processing MALDI/TOF Mass Spectra by Using Geena 2. Curr Protoc Bioinformatics 2018 Dec;64(1):e59. doi: 10.1002/cpbi.59. Epub 2018 Nov 13.
  • Romano P, Varese GC. Microbial Resource Research Infrastructure: stato e prospettive sull’integrazione dei dati. Atti Conferenza GARR 2017 – The data way to Science. Venezia, 15-17 novembre 2017. Associazione Consortium GARR. ISBN 978-88-905077-7-9 doi: 10.26314/GARR-Conf17-proceedings-08
  • Saturnino C, Caruso A, Iacopetta D, Rosano C, Ceramella J, Muià N, Mariconda A, Bonomo MG, Ponassi M, Rosace G, Sinicropi MS, Longo P. Inhibition of Human Topoisomerase II by N,N,N-Trimethylethanammonium Iodide Alkylcarbazole Derivatives. ChemMedChem 2018 Dec 20;13(24):2635-2643. doi: 10.1002/cmdc.201800546. Epub 2018 Nov 30.
  • Sinicropi MS, Iacopetta D, Rosano C, Randino R, Caruso A, Saturnino C, Muià N, Ceramella J, Puoci F, Rodriquez M, Longo P, Plutino MR. N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation. J Enzyme Inhib Med Chem 2018 Dec;33(1):434-444. doi: 10.1080/14756366.2017.1419216.
  • Ventura F, Barranco R, Bachetti T, Nozza P, Fulcheri E, Palmieri A, Ceccherini I. Medico-legal investigation in an explicable case of congenital central hypoventilation syndrome due to a rare variant of the PHOX2B gene. J Forensic Leg Med 2018, 58:1-5. doi: 10.1016/j.jflm.2018.04.009
  • Viale M, Monticone M, Maric I, Giglio V, Profumo AAprile A, Cilli M, Abelmoschi ML, Rocco M. Characterization of drug release from fibrin gels loaded with different pharmaceutical and experimental doxorubicin formulations. Pharmacol Rep 2018 Aug;70(4):760-765. doi: 10.1016/j.pharep.2018.02.014. Epub 2018 Feb 21

2017

  • Anzaldi M, Viale M, Macciò C, Castagnola P, Oliveri V, Rosano C, Balbi A. Synthesis of short retinoidal amides related to fenretinide: antioxidant activities and differentiation-inducing ability. Cancer Chemother Pharmacol 2017 Apr;79(4):725-736. doi: 10.1007/s00280-017-3265-1. Epub 2017 Mar 9.
  • Banelli B, Daga A, Forlani A, Allemanni G, Marubbi D, Pistillo MP, Profumo A, Romani M. Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. Oncotarget 2017 May 23;8(21):34896-34910. doi: 10.18632/oncotarget.16820.
  • Brizzolara A, Benelli R, Venè R, Barboro P, Poggi A, Tosetti F, Ferrari N. The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer. Cancer Letters 2017, 400:9-17. doi: 10.1016/j.canlet.2017.04.025
  • Cattrini C, Zanardi E, Vallome G, Cavo A, Cerbone L, Di Meglio A, Fabbroni C, Latocca MM, Rizzo F, Messina C, Rubagotti A, Barboro P, Boccardo F. Targeting androgen-independent pathways: new chances for patients with prostate cancer? Critical Reviews in Oncology/Hematology 2017,118:42-53. doi: 10.1016/j.critrevonc.2017.08.009
  • Di Zanni E, Adamo A, Belligni E, Lerone M, Martucciello G, Mattioli G, Pini Prato A, Ravazzolo R, Silengo M, Bachetti T, Ceccherini I. Common PHOX2B poly-alanine contractions impair RET gene transcription, predisposing to Hirschsprung disease. Biochim Biophys Acta. 2017, 1863(7):1770-1777. doi: 10.1016/j.bbadis.2017.04.017
  • Di Zanni E, Bianchi G, Ravazzolo R, Raffaghello L, Ceccherini I, Bachetti T. Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth. Oncotarget. 2017, 8(42):72133-72146. doi: 10.18632/oncotarget.19922
  • Ferrari N, Granata I, Capaia M, Piccirillo M, Guarracino MR, Venè R, Brizzolara A, Petretto A, Inglese E, Morini M, Astigiano S, Amaro AA, Boccardo F, Balbi C, Barboro P. Adaptive phenotype drives resistance to androgen deprivation therapy in prostate cancer. Cell Communication and Signaling 2017, 15:51. doi: 10.1186/s12964-017-0206-x
  • Gaëta BA, De Las Rivas J, Horton P, Meysman P, Mulder N, Romano P, Welch L. Ten simple rules for forming a Scientific Professional Society. PLoS Computational Biology 2017, 13(3):e1005226 doi: 10.1371/journal.pcbi.1005226
  • Garbati P, Ravera S, Scarfì S, Salis A, Rosano C, Poggi A, Damonte G, Millo E, Balestrino M. Effects on Energy Metabolism of Two Guanidine Molecules, (Boc)2 -Creatine and Metformin. J Cell Biochem 2017 Sep;118(9):2700-2711. doi: 10.1002/jcb.25914. Epub 2017 Feb 13.
  • Geretto M, Pulliero A, Rosano C, Zhabayeva D, Bersimbaev R, Izzotti A. Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators. Am J Cancer Res 2017 Jun 1;7(6):1350-1371. eCollection 2017.
  • Gordya N, Yakovlev A, Kruglikova A, Tulin D, Potolitsina E, Suborova T, Bordo D, Rosano C, Chernysh S. Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots. PLoS One 2017 Mar 9;12(3):e0173559. doi: 10.1371/journal.pone.0173559. eCollection 2017.
  • Iacopetta D, Grande F, Caruso A, Mordocco RA, Plutino MR, Scrivano L, Ceramella J, Muià N, Saturnino C, Puoci F, Rosano C, Sinicropi MS. New insights for the use of quercetin analogs in cancer treatment. Future Med Chem 2017 Nov;9(17):2011-2028. doi: 10.4155/fmc-2017-0118. Epub 2017 Oct 27.
  • Iacopetta D, Rosano C, Puoci F, Parisi OI, Saturnino C, Caruso A, Longo P, Ceramella J, Malzert-Fréon A, Dallemagne P, Rault S, Sinicropi MS. Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors. Eur J Pharm Sci 2017 Jan 1;96:263-272. doi: 10.1016/j.ejps.2016.09.039. Epub 2016 Oct 1.
  • Panfoli I, Ponassi M, Ravera S, Calzia D, Beitia M, Morelli A, Rosano C. Tracking protons from respiratory chain complexes to ATP synthase c-subunit: The critical role of serine and threonine residues. Biochem Biophys Res Commun 2017 Jan 22;482(4):922-927. doi: 10.1016/j.bbrc.2016.11.134. Epub 2016 Nov 25.
  • Pizzirusso A, De Nicola A, Sevink A, Correa A, Cascella M, Kawakatsu T, Rocco M, Zhao Y, Celino M, Milano G. Biomembrane Solubilization Mechanism by Triton X-100: A Computational Study of The Three Stage Model. Phys. Chem. Chem. Phys. 2017, 19, 29780-29794. doi: 10.1039/C7CP03871B
  • Romano P, Biobanks for biomedical research. In “E-Health – Medicina Digitale“, Cesarelli M, Giacomini M, Pinciroli F, Quaglini S (Eds.), Pàtron Editore, Bologna. Gruppo Nazionale di Bioingegneria n. 36. 2017. pp. 265-275. ISBN 978-88-555-3387-4.
  • Romano P. Bioinformatics activities at the University Hospital San Martino IST in Genoa. EMBnet.journal 2017, 22, e884. doi: 10.14806/ej.23.0.884
  • Romano P, Hofestädt R, Lange M, D’Elia D. The joint NETTAB / Integrative Bioinformatics 2015 Meeting: aims, topics and outcomes. BMC Bioinformatics 2017, 18(Suppl 5):101 doi: 10.1186/s12859-017-1532-0
  • Smith D, Stackebrandt E, Casaregola S, Romano P, Glöckner FO. MIRRI Recommendations for Exploiting the Full Potential of Micro-Organism Data. Ann Biom Biostat 4(1):1027, 2017.
  • Zocchi MR, Costa D, Venè R, Tosetti F, Ferrari N, Minghelli S, Benelli R, Scabini S, Romairone E, Catellani S, Profumo A, Poggi A. Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity. Oncoimmunology 2017 Jan 6;6(3):e1278099. doi: 10.1080/2162402X.2016.1278099. eCollection 2017.

2016

  • Brookes E, Rocco M. Calculation of hydrodynamic parameters – US-SOMO. In: Arisaka F, Laue T, Stafford WF, Uchiyama S (Eds.), Analytical ultracentrifugation – Instrumentation, analysis and applications. Springer, 2016, Chapter 10, pp. 169-194. https://www.springer.com/la/book/9784431559832
  • Brookes E, Vachette P, Rocco M, Pérez J. US-SOMO HPLC-SAXS module: dealing with capillary fouling and extraction of pure component patterns from poorly resolved SEC-SAXS data. J. Appl. Cryst. 2016, 49, 1827-1841 doi: 10.1107/S1600576716011201
  • Casaregola S, Vasilenko A, Romano P, Robert V, Ozerskaya S, Kopf A, Glöckner FO, Smith D. An Information System for European culture collections: the way forward. SpringerPlus 2016, 5(1):772 doi: 10.1186/s40064-016-2450-8
  • Colobraro DP, Romano P. A Galaxy approach to microbial data integration: the USMI Galaxy Demonstrator. Conference Proceedings 12th BITS Annual Meeting, June 3-5, 2015, Milano, Italy. Milanesi L, Mauri G, Masseroli M (Eds). BUP – Bononia University Press SpA, Bologna Italy, 2016, pp. 43-45. ISBN 978-88-6923-125-4
  • Gioria S, Lobo Vicente J, Barboro P, La Spina R, Tomasi G, Urbán P, Kinsner-Ovaskainen A, François R, Chassaigne H. A combined proteomics and metabolomics approach to assess the effects of gold nanoparticles in vitro. Nanotoxicology 2016, 10(6):736-748. doi: 10.3109/17435390.2015.1121412
  • Ison J, Rapacki K, Ménager H, Kalaš M, Rydza E, Chmura P, Anthon C, Beard N, Berka K, Bolser D, Booth T, Bretaudeau A, Brezovsky J, Casadio R, Cesareni G, Coppens F, Cornell M, Cuccuru G, Davidsen K, Vedova GD, Dogan T, Doppelt-Azeroual O, Emery L, Gasteiger E, Gatter T, Goldberg T, Grosjean M, Grüning B, Helmer-Citterich M, Ienasescu H, Ioannidis V, Jespersen MC, Jimenez R, Juty N, Juvan P, Koch M, Laibe C, Li JW, Licata L, Mareuil F, Mičetić I, Friborg RM, Moretti S, Morris C, Möller S, Nenadic A, Peterson H, Profiti G, Rice P, Romano P, Roncaglia P, Saidi R, Schafferhans A, Schwämmle V, Smith C, Sperotto MM, Stockinger H, Vařeková RS, Tosatto SC, de la Torre V, Uva P, Via A, Yachdav G, Zambelli F, Vriend G, Rost B, Parkinson H, Løngreen P, Brunak S. Tools and data services registry: a community effort to document bioinformatics resources. Nucl. Acids Res. (2016) 44(D1):D38-D47. Epub 2015 Nov 3 doi: 10.1093/nar/gkv1116
  • Klionski et al (incl. Bachetti T) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 12(1):1-222. doi: 10.1080/15548627.2015.1100356
  • Lappano R, Rigiracciolo D, De Marco P, Avino S, Cappello AR, Rosano C, Maggiolini M, De Francesco EM. Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling. AAPS J 2016 Mar;18(2):305-10. doi: 10.1208/s12248-016-9881-6. Epub 2016 Feb 10. Review.
  • Romano P, Amaro AA, Pfeffer U. MultiTargetScan. Conference Proceedings 12th BITS Annual Meeting, June 3-5, 2015, Milano, Italy. Milanesi L, Mauri G, Masseroli M (Eds). BUP – Bononia University Press SpA, Bologna Italy, 2016, pp. 121-123. ISBN 978-88-6923-125-4
  • Romano P, Cordero F. NETTAB 2014: From high-throughput structural bioinformatics to integrative systems biology. BMC Bioinformatics 2016, 17(Suppl 4):62 doi: 10.1186/s12859-016-0907-y
  • Romano PProfumo ARocco M, Mangerini R, Ferri F, Facchiano A. Geena 2, improved automated analysis of MALDI/TOF mass spectra. BMC Bioinformatics 2016 Mar 2;17 Suppl 4:61. doi: 10.1186/s12859-016-0911-2.
  • Rosano CPonassi M, Santolla MF, Pisano A, Felli L, Vivacqua A, Maggiolini M, Lappano R. Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands. AAPS J 2016 Jan;18(1):41-6. doi: 10.1208/s12248-015-9844-3. Epub 2015 Nov 16. Review.
  • Saturnino C, Barone I, Iacopetta D, Mariconda A, Sinicropi MS, Rosano C, Campana A, Catalano S, Longo P, Andò S. N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression. Future Med Chem 2016 Dec;8(18):2213-2229. Epub 2016 Nov 22.
  • Ventura E, Cordazzo C, Quarto R, Zardi L, Rosano C. C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8. PLoS One 2016 Feb 11;11(2):e0148103. doi: 10.1371/journal.pone.0148103. eCollection 2016.

2015

  • Attwood TK, Banag Cl, Blackford S, Blatter MC, Bongcam-Rudloff E, Brazas MD, Brooksbank C, Budd A, Charleston M, Christoffels A, Conesa A, Corpas M, Crowe M, Davies A, de Crecy-Lagard V, De Las Rivas J, Doyle M, Edwards R, Facchiano A, Fernandes P, Gaeta B, Gaudet P, Heger A, Herringa J, Hughes D, Jimenez RC, Kille P, Korpelainen E, Kumuthini J, Lewitter F, MacLean D, Martinez SAR, McGrath A, Michalopoulos I, Mulder N, Ouellette BF, Palagi PM, Pearson WR, Qi W, Romano P, Rother K, Sansone SA, Schneider MV, Schönbach C, Tastan-Bishop O, Trelles O, Twells R, van Gelder CWG, Via A, Vriend G, Warnow T, Watson M, Westervelt N, Zanzoni A. GOBLET: The Global Organisation for Bioinformatics Learning, Education and Training. PLoS Computational Biology 11(4), 1 April 2015, e1004143 doi: 10.1371/journal.pcbi.1004143
  • Bachetti T, Di Zanni E, Ravazzolo R, Ceccherini I. miR-204 mediates post-transcriptional down-regulation of PHOX2B gene expression in neuroblastoma cells. Biochim Biophys Acta. 2015, 1849(8):1057-65. doi: 10.1016/j.bbagrm.2015.06.008
  • Barboro P, Ferrari N, Capaia M, Petretto A, Salvi S, Boccardo S, Balbi C. Expression of nuclear matrix proteins binding matrix attachment regions in prostate cancer. PARP‐1: New player in tumor progression. Int. J. Cancer 2015, 137(7):1574-1586. doi: 10.1002/ijc.29531
  • Boccardo F, Rubagotti A, Nuzzo PV, Argellati F, Savarino G, Romano P, Damonte G, Rocco MProfumo A. Matrix-assisted laser desorption/ionisation (MALDI) TOF analysis identifies serum angiotensin II concentrations as a strong predictor of all-cause and breast cancer (BCa)-specific mortality following breast surgery. Int J Cancer 2015 Nov 15;137(10):2394-402. doi: 10.1002/ijc.29609. Epub 2015 Jun 4.
  • Cafeo G, Kohnke FH, Mezzatesta G, Profumo ARosano C, Villari A, White AJ. Host-guest chemistry of a bis-calix[4]pyrrole derivative containing a trans/cis-switchable azobenzene unit with several aliphatic bis-carboxylates. Chemistry 2015 Mar 27;21(14):5323-7. doi: 10.1002/chem.201406183. Epub 2015 Feb 24.
  • Coco S, Truini A, Vanni I, Genova C, Rosano C, Dal Bello MG, Alama A, Venè R, Rijavec E, Barletta G, Biello F, Boccardo F, Grossi F. Uncommon EGFR Exon 19 Mutations Confer Gefitinib Resistance in Advanced Lung Adenocarcinoma. J Thorac Oncol 2015 Jun;10(6):e50-2. doi: 10.1097/JTO.0000000000000538.
  • De Nicola A, Kawakatsu T, Rosano C, Celino M, Rocco M, Milano G. Self-assembly of triton X-100 in water solutions: a multiscale simulation study linking mesoscale to atomistic models. J Chem Theory Comput 2015 Oct 13;11(10):4959-71. doi: 10.1021/acs.jctc.5b00485. Epub 2015 Aug 28.
  • Demori I, Lanaro D, Strangio A, Iervasi E, Saverino D. Evaluation of neuroendocrine parameters during osteopathic manipulative treatment (OMT). Eur J Integr Med 2015, 7(1):4. DOI: 10.1016/j.eujim.2015.09.016
  • Di Zanni E, Fornasari D, Ravazzolo R, Ceccherini I, Bachetti T. Identification of novel pathways and molecules able to down-regulate PHOX2B gene expression by in vitro drug screening approaches in neuroblastoma cells. Exp Cell Res. 2015, 336(1):43-57. doi: 10.1016/j.yexcr.2015.03.025
  • Facchiano A, Angelini C, Bosotti R, Guffanti A, Marabotti A, Marangoni R, Pascarella S, Romano P, Zanzoni A, Helmer-Citterich M. Preface: BITS2014, the annual meeting of the Italian Society of Bioinformatics. BMC Bioinformatics 2015, 16(Suppl 9):S1 doi: 10.1186/1471-2105-16-S9-S1
  • Ferri F, Re Calegari G, Molteni M, Cardinali B, Magatti D, Rocco M. Size and density of fibers in fibrin and other filamentous networks from turbidimetry: beyond a revisited Carr-Hermans method, accounting for fractality and porosity. Macromolecules 2015, 48, 5423–5432 doi: 10.1021/acs.macromol.5b00893
  • Lappano R, Rosano C, Pisano A, Santolla MF, De Francesco EM, De Marco P, Dolce V, Ponassi M, Felli L, Cafeo G, Kohnke FH, Abonante S, Maggiolini M. A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models. Dis Model Mech 2015 Oct 1;8(10):1237-46. doi: 10.1242/dmm.021071. Epub 2015 Jul 16.
  • Maggiolini M, Santolla MF, Avino S, Aiello F, Rosano C, Garofalo A, Grande F. Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts. Future Med Chem 2015;7(4):437-48. doi: 10.4155/fmc.15.3.
  • Rocco M, Byron O. Computing translational diffusion and sedimentation coefficients: an evaluation of experimental data and programs. Eur. Biophys. J. 2015, 44, 417–431 doi: 10.1007/s00249-015-1042-9
  • Rocco M, Byron O. Hydrodynamic modeling and its application in AUC. In: Cole J (Ed.), Analytical Ultracentrifugation, Methods in Enzymology, 2015, Volume 562, Chapter 4, pages 81-108, Elsevier. doi: 10.1016/bs.mie.2015.04.010
  • Rocco M, Weisel JW. Exposed: the elusive αC regions in fibrinogen, fibrin protofibrils and fibers (Commentary). J. Thromb. Haemost. 2015, 13,1-3.
  • Saverino D, Pierantozzi E, Muroni MR, Strangio A, Iervasi E. Anti-inflammatory and stress responses after intense vs moderate judo exercise in children. Eur J Integr Med 2015, 7(1):21-22. DOI: 10.1016/j.eujim.2015.09.055
  • Sinicropi MS, Lappano R, Caruso A, Santolla MF, Pisano A, Rosano C, Capasso A, Panno A, Lancelot JC, Rault S, Saturnino C, Maggiolini M. (6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells. Curr Top Med Chem 2015;15(11):1035-42.
  • Vecchio D, Daga A, Carra E, Marubbi D, Raso A, Mascelli S, Nozza P, Garrè ML, Pitto F, Ravetti JL, Vagge S, Corvò R, Profumo A, Baio G, Marcello D, Frosina G. Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019. Int J Cancer 2015 Mar 15;136(6):1445-57. doi: 10.1002/ijc.29121.Epub 2014 Aug 11.
  • Viale M, Rossi M, Russo E, Cilli M, Aprile AProfumo A, Santi P, Fenoglio C, Cafaggi S, Rocco M. Fibrin gels loaded with cisplatin and cisplatin-hyaluronate complexes tested in a subcutaneous human melanoma model. Invest New Drugs 2015 Dec;33(6):1151-61. doi: 10.1007/s10637-015-0291-x.Epub 2015 Oct 7.